Accomplishments

Our success so far…

Publications

The cilia concept that forms the basis of our company is published in multiple in leading biomedical research journals. 

• Eisa-Beygi S, Benslimane FM, El-Rass S, Prabhudesai S, Khatib Ali Abdelrasool M, Simpson PM, Yalcin HC, Burrows PE and Ramchandran R. Characterization of endothelial cilia distribution during cerebral-vascular development in zebrafish (danio rerio)***. 2018. ATVB. PMID:  30571172. **Inside ATVB editorial: Before the Pump: The Importance of Cilia in Cranial Development. 
• Gupta A, Thirugnanam K, Thamilarasan M, Mohieldin AM, Al-Jighefee HT, Prabhudesai S, Griffin M, Spearman AD, Pan A, Palecek SP, Yalcin HC, Nauli SM, Rarick K, Zennadi R and Ramchandran R. Cilia proteins are biomarkers of altered flow in the vasculature. 2022. JCI Insight. PMID: 351433420.
• Thirugnanam K, Prabhudesai S, Van Why E, Pan A, Gupta A, Foreman K, Zennadi R, Rarick KR, Nauli SM, Palecek SP and Ramchandran R. Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability. 2022. Biochemical Pharmacology. PMID: 35700757. 
• Thirugnanam K, Gupta A, Nunez F, Prabhudesai SP, Pan AY, Nauli S, Ramchandran R. Brain microvascular endothelial cells possess a second cilium from the daughter centriole. 2023. Frontiers in Molecular Biosciences. PMID: 38028541. 

Funding

• Cilia Biomarker Kit Development for Brain Injury Diagnosis and Prognosis, 1R41 NS139906-01A1, STTR Phase I, 2 years, $699,000. 
• Ciliary Biomarkers of Injury. GenScript. 1 year $15,000.