Accomplishments

Our success so far…

Publications

The cilia concept that forms the basis of our company is published in multiple in leading biomedical research journals. 

• Eisa-Beygi S, Benslimane FM, El-Rass S, Prabhudesai S, Khatib Ali Abdelrasool M, Simpson PM, Yalcin HC, Burrows PE and Ramchandran R. Characterization of endothelial cilia distribution during cerebral-vascular development in zebrafish (danio rerio)***. 2018. ATVB. PMID:  30571172. **Inside ATVB editorial: Before the Pump: The Importance of Cilia in Cranial Development. 
• Gupta A, Thirugnanam K, Thamilarasan M, Mohieldin AM, Al-Jighefee HT, Prabhudesai S, Griffin M, Spearman AD, Pan A, Palecek SP, Yalcin HC, Nauli SM, Rarick K, Zennadi R and Ramchandran R. Cilia proteins are biomarkers of altered flow in the vasculature. 2022. JCI Insight. PMID: 351433420.
• Thirugnanam K, Prabhudesai S, Van Why E, Pan A, Gupta A, Foreman K, Zennadi R, Rarick KR, Nauli SM, Palecek SP and Ramchandran R. Ciliogenesis mechanisms mediated by PAK2-ARL13B signaling in brain endothelial cells is responsible for vascular stability. 2022. Biochemical Pharmacology. PMID: 35700757. 
• Thirugnanam K, Gupta A, Nunez F, Prabhudesai SP, Pan AY, Nauli S, Ramchandran R. Brain microvascular endothelial cells possess a second cilium from the daughter centriole. 2023. Frontiers in Molecular Biosciences. PMID: 38028541. 
• Mohieldin AM, Spencer M, Bernal C, Fadol WB, Gupta A, Thirugnanam K, Delahunty C, Nunez F, Pan A, Palecek SP, Rarick KR, Ramchandran R, Zennadi R, Yates J, Nauli SM. Cilia Proteome as Biomarker for Underlying Vascular Injury in Sickle Cell Disease. 2025. Journal of Proteome Research***. PMID: 40374167

Funding

• Cilia Biomarker Kit Development for Brain Injury Diagnosis and Prognosis, 1R41 NS139906-01A1, STTR Phase I, 2 years, $699,000.